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XBP1 acts downstream of Blimp-1 to expand the secretory apparatus, promote organelle biogenesis, and increase protein synthesis during plasma cell differentiation

A.L. Shaffer 1, Miriam Shapiro-Shelef 2, Neal N. Iwakoshi 3, Shu-Bing Qian 4, Hong Zhao 1, Xin Yu 1, Liming Yang 1, Bruce K. Tan 1, Andreas Rosenwald 1, Elaine M. Hurt 1, Emmanuel Petroulakis 5, Nahum Sonenberg 5, Jonathan W. Yewdell 4, Kathryn Calame 2, Laurie H. Glimcher 3, and Louis M. Staudt 1

1- Metabolism Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892.
2- Department of Microbiology and Integrated Program in Biophysical, Cellular and Molecular Studies, Columbia University College of Physicians and Surgeons, New York, NY 10032.
3- Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115.
4- Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
5- McGill University, Department of Biochemistry, Montreal, Quebec Canada H3G 1Y6

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National Institutes of Health | National Cancer Institute
Center for Cancer Research | Lymphoid Malignancies Branch