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Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program
A.L Shaffer*(1), Kuo-I. Lin*(2), Tracy C. Kuo (2), Xin Yu (1), Elaine M. Hurt (1), Andreas Rosenwald (1), Jena M. Giltnane (1), Liming Yang (1), Hong Zhao (1), Kathryn Calame&(2), Louis M. Staudt&(1)
(1) Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md 20892
(2) Departments of Microbiology and Biochemistry & Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, N.Y. 10032
*These authors contributed equally to the work
&These senior investigators contributed equally to this work and are corresponding authors:
(K.C. email@example.com or L.M.S. firstname.lastname@example.org)
Address correspondance to:
Louis M. Staudt, M.D., Ph.D.
Metabolism Branch, CCR, NCI
Bldg. 10, Rm. 4N114
NIH, Bethesda, MD 20892
Kathryn Calame, Ph.D.
Professor, Microbiology and Biochemistry & Molecular Biophysics
Columbia University College of Physicians and Surgeons
701 W. 168th Street
New York, N.Y. 10032
Index of Supplementary Contents
Gene expression data for Figure 1. can be downloaded as an Excel file here
Gene expression data for Figure 2. can be downloaded as an Excel file here
Web Figure 1: RT-PCR and Flow Cytometry
Web Figure 2: Confirmation of BCL-6 as a Blimp-1 Target
Web Table 1: Targets of Blimp-1 Action
Web Table 2: Target gene consistency across experimental systems
Materials and Methods: Materials and Methods
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