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Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program

A.L Shaffer*(1), Kuo-I. Lin*(2), Tracy C. Kuo (2), Xin Yu (1), Elaine M. Hurt (1), Andreas Rosenwald (1), Jena M. Giltnane (1), Liming Yang (1), Hong Zhao (1), Kathryn Calame&(2), Louis M. Staudt&(1)

(1) Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md 20892
(2) Departments of Microbiology and Biochemistry & Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, N.Y. 10032
*These authors contributed equally to the work
&These senior investigators contributed equally to this work and are corresponding authors:
(K.C. klc1@columbia.edu or L.M.S. lstaudt@mail.nih.gov)

Address correspondance to:
Louis M. Staudt, M.D., Ph.D.
Metabolism Branch, CCR, NCI
Bldg. 10, Rm. 4N114
NIH, Bethesda, MD 20892
(301)-402-1892 (office)
(301)-496-9956 (fax)

Kathryn Calame, Ph.D.
Professor, Microbiology and Biochemistry & Molecular Biophysics
Columbia University College of Physicians and Surgeons
701 W. 168th Street
New York, N.Y. 10032
(212)-305-3504 (office)
(212)-305-1468 (fax)

Index of Supplementary Contents

Gene expression data for Figure 1. can be downloaded as an Excel file here

Gene expression data for Figure 2. can be downloaded as an Excel file here

Web Figure 1: RT-PCR and Flow Cytometry

Web Figure 2: Confirmation of BCL-6 as a Blimp-1 Target

Web Table 1: Targets of Blimp-1 Action

Web Table 2: Target gene consistency across experimental systems

Materials and Methods: Materials and Methods

Note on downloading data:

For PC Users:
1) Right Click on "here"
2) Internet Explorer: "save target as" or Netscape: "save link as"
3) Open with Excel

For Mac Users:
1) Hold down mouse button
2) Internet Explorer: "download link to disk" or Netscape: "save link as", and change format to "source"
3) Open with Excel


National Institutes of Health | National Cancer Institute
Center for Cancer Research | Lymphoid Malignancies Branch